Association of <i>MAP3K1 rs889312</i> genotypes with OS in gastric cancer patients.

<p>(A) In intestinal-type gastric cancer patients, the heterozygous variant genotype (AC) did not show significant association with survival outcomes; (B) In diffuse-type gastric cancer patients, individuals with the AC genotype had a significantly increased risk of death when compared with those carrying the homozygous variant genotypes (AA/CC). HR and 95% CIs were estimated using multivariate Cox regression model. Statistical differences between two survival curves were assessed by the log-rank test. Asterisks (*) indicates mean OS when median OS could not be calculated. ^†The log-rank <i>P</i> value less than 0.05 was corrected by a permutation test (n = 5000 random permutations) reported by Vasselli et al <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0096083#pone.0096083-Vasselli1" target="_blank">[17]</a>.