Enhanced infiltration of lymphocytes in testes of mice deficient in EBI3, p35, and IL-12Rβ2.

<p>(A) Cryostat sections of testes of WT mice and deficient mice (12 weeks old; <i>n</i> = 5 per group) were immunohistochemically stained with anti-CD4, anti-CD8, or anti-B220. The sections were also counterstained with methyl green. Representative histology images are shown. Positive cells are shown as gray spots. Dashed line indicates basal lamina of the seminiferous tubules. (B) The histopathological changes were evaluated by counting the number of infiltrating lymphocytes per square millimeter of testicular interstitium. Data are shown as mean ± SD. *<i>P</i><0.05. Similar results were obtained in more than two independent experiments. KO, knockout.