TM^pro/pro mice demonstrate increased coagulation activation after infection with <i>B. pseudomallei</i>.

<p>Mice were inoculated intranasally with 750<i>B. pseudomallei</i> and sacrificed after 24, 48 and 72 hours. Coagulation activation in lung homogenates (A) and plasma (B), as reflected by levels of TATc. Lung D-dimer levels in TM^pro/pro mice (C). Data are expressed as box and whisker plots showing the smallest observation, lower quartile, median, upper quartile and largest observation. Grey and white boxes represent WT and TM^pro/pro mice respectively (<i>n</i> = 8 mice/group). *<i>P</i><0.05 and **<i>P</i><0.01 for the difference between WT and TM^pro/pro mice (Mann-Whitney <i>U</i> test).