Ruthenium-Catalyzed Direct C–H Amidation of Arenes: A Mechanistic Study
- Lu−Lu Zhang (1816288)
- Lian-Hua Li (1413190)
- Yu-Qi Wang (1538104)
- Yan-Fang Yang (1816291)
- Xue-Yuan Liu (553967)
- Yong-Min Liang (1393099)
DOIAbstract
We report mechanistic studies of C–H activitation/amidation reactions using azides as the amino source catalyzed by [RuCl<sub>2</sub>(<i>p</i>-cymene)]<sub>2</sub>. We have achieved two intermediates in the catalytic cycle (C<sub>5</sub>H<sub>4</sub>NC<sub>6</sub>H<sub>4</sub>)Ru(<i>p</i>-cymene)Cl and (C<sub>5</sub>H<sub>4</sub>NC<sub>6</sub>H<sub>4</sub>)NArRu(<i>p</i>-cymene)Cl (Ar = NO<sub>2</sub>C<sub>6</sub>H<sub>4</sub>SO<sub>2</sub>). Furthermore, the process from (C<sub>5</sub>H<sub>4</sub>NC<sub>6</sub>H<sub>4</sub>)Ru(<i>p</i>-cymene)Cl to (C<sub>5</sub>H<sub>4</sub>NC<sub>6</sub>H<sub>4</sub>)NArRu(<i>p</i>-cymene)Cl was monitored by <sup>19</sup>F NMR and a ruthenium–imido species was proposed to explain the formation o...
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