Cis-inhibiting interactions increase the ratio of high-ligand expressing cells.

<p>(A) Stationary patterns of ligand levels arising from precursor cells with small initial variability between them for different inhibiting cis-interactions strengths . Color code as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0095744#pone-0095744-g003" target="_blank">Fig. 3A</a>. (B) Ratio of stationary high-ligand fated cells as a function of the cis-interactions strength when precursor cells show small (red triangles) and large (blue circles) initial variability between them. (C) Density plot representing the ratio of high-ligand cells in a tissue arising from precursor cells exhibiting large initial variability. Solid and dashed lines as defined in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0095744#pone-0095744-g003" target="_blank">Fig. 3B</a>–D. White vertical line is drawn for indicating the value along which simulations are performed in panels A, B and D. (D) Stationary patterns of ligand levels arising from precursor cells with large initial variability between them for different inhibiting cis-interactions strengths . In B–C panels, cells are considered high-ligand fated cells when its ligand level is over the threshold of . Parameter values: , , and for all panels. Similar results are found for (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0095744#pone.0095744.s005" target="_blank">Fig. S5</a>). In B, each point comes from the average of numerical integrations of the dynamics on a lattice of irregular cells starting at different initial conditions. In C, the results correspond to numerical integration of the dynamics performed over a lattice of perfect hexagonal cells.