CXCLs increased the migration and invasion of human pancreatic cancer cells.

<p>Migration and invasion assays were performed on Capan1 cells treated with vehicle, 100/ml CXCL1, 2, and 8, or their antognists 20 µg/ml anti-CXCR1 antibody and 400 nM SB 225002 as indicated, using transwell cell chambers. The number of cells that invaded the membrane was counted in 10 fields under the ×20 objective lens. Original magnification, ×200. The results are presented as the means±SD of values obtained in three independent experiments. The statistical significance was calculated using ANOVA. *<i>P</i> < 0.05.