Iron deposits and ferritin staining are colocalized in the same subset of macrophages (A) Costaining for ferritin and CD68 and (A’) with Perls-DAB and CD68 in two adjacent lung sections from a GOLD 4 COPD patient.

The IRONy of Iron-overload and Iron-deficiency in Chronic Obstructive Pulmonary Disease.

Cloonan, SM
Mumby, S
Adcock, IM
Choi, AMK
Chung, KF
Quinlan, GJ

April 2017

Chronic obstructive pulmonary disease (COPD) is a debilitating inflammatory lung disease associated ...

Preferential Macrophage Recruitment and Polarization in LPS-Induced Animal Model for COPD: Noninvasive Tracking Using MRI

Achraf Al Faraj (530923)
Asma Sultana Shaik (530924)
Mary Angeline Pureza (530925)
Mohammad Alnafea (530926)
Rabih Halwani (287270)

March 2014

<div><p>Noninvasive imaging of macrophages activity has raised increasing interest for diagnosis of ...

Hemosiderin in sputum macrophages may predict infective exacerbations of chronic obstructive pulmonary disease: a retrospective observational study

Sindu Mohan
Terence Ho
Melanie Kjarsgaard
Katherine Radford
A. S. M. Borhan
Lehana Thabane
Parameswaran Nair

April 2017

Abstract Background Infective exacerbations of COPD are common and are accompanied by neutrophilic b...

Iron is localized in macrophages in lung of COPD subjects and the percentage of iron positive macrophage increases with severity of disease.

Quentin Philippot (558140)
Gaëtan Deslée (3569186)
Tracy L. Adair-Kirk (307367)
Jason C. Woods (558141)
Derek Byers (558142)
Susan Conradi (558143)
Sandra Dury (59720)
Jeanne Marie Perotin (558144)
François Lebargy (59727)
Christelle Cassan (558145)
Richard Le Naour (359763)
Michael J. Holtzman (166602)
Richard A. Pierce (558146)

May 2014

<p>Perls-DAB and CD68 costaining was performed in lung samples obtained from (A–A’) a patient withou...

Flow cytometry analysis of alveolar macrophages in control/control, COPD/Control (48 h post LPS intrapulmonary exposition), COPD/M1 and COPD/M2 (2 h post-injection of iron-labeled macrophages) groups for both retained (i.e., iron loaded) and retained fractions.

Achraf Al Faraj (530923)
Asma Sultana Shaik (530924)
Mary Angeline Pureza (530925)
Mohammad Alnafea (530926)
Rabih Halwani (287270)

March 2014

<p>a- representative histogram of CD86 expression (higher row) and CD206 (lower row). b- Surface mem...

Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease.

Quentin Philippot
Gaëtan Deslée
Tracy L Adair-Kirk
Jason C Woods
Derek Byers
Susan Conradi
Sandra Dury
Jeanne Marie Perotin
François Lebargy
Christelle Cassan
Richard Le Naour
Michael J Holtzman
Richard A Pierce

Free iron in lung can cause the generation of reactive oxygen species, an important factor in chroni...

Increased Iron Sequestration in Alveolar Macrophages in Chronic Obtructive Pulmonary Disease

Quentin Philippot (558140)
Gaëtan Deslée (3569186)
Tracy L. Adair-Kirk (307367)
Jason C. Woods (558141)
Derek Byers (558142)
Susan Conradi (558143)
Sandra Dury (59720)
Jeanne Marie Perotin (558144)
François Lebargy (59727)
Christelle Cassan (558145)
Richard Le Naour (359763)
Michael J. Holtzman (166602)
Richard A. Pierce (558146)

May 2014

<div><p>Free iron in lung can cause the generation of reactive oxygen species, an important factor i...

Expression of CD73 and the A<sub>2B</sub>R in M2 macrophages.

Yang Zhou (65942)
Jayasimha N. Murthy (367141)
Dewan Zeng (367144)
Luiz Belardinelli (180279)
Michael R. Blackburn (104598)

February 2013

<p>Lung sections from COPD or IPF patients were reacted with antibodies against CD73 (A, green) or t...

ToF-SIMS mediated analysis of human lung tissue reveals increased iron deposition in COPD (GOLD IV) patients

Najafinobar, Neda
Venkatesan, Shalini
von Sydow, Lena
Klarqvist, Magnus
Olsson, Henric
Zhou, Xiao Hong
Cloonan, Suzanne M.
Malmberg, Per

January 2019

Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease that is currently the th...

Ferritin accumulated in medullary interstitial macrophages: Kidney sections from PIO mice were co-stained with anti-CD-68 and L-ferritin antibodies.

Avital Weiss (3490031)
Lior Spektor (5855732)
Lyora A. Cohen (5855735)
Lena Lifshitz (3202965)
Inbar Magid Gold (5855738)
De-Liang Zhang (5855741)
Marianna Truman-Rosentsvit (5855744)
Yael Leichtmann-Bardoogo (5855747)
Abraham Nyska (371249)
Sefi Addadi (1456258)
Tracey A. Rouault (126059)
Esther G. Meyron-Holtz (119365)

October 2018

Co-localization can be observed as yellow regions in the right panel. Scale bar represents 50μm.</p

Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS.

Zhang, William Z
Oromendia, Clara
Kikkers, Sarah Ann
Butler, James J
O'Beirne, Sarah
Kim, Kihwan
O'Neal, Wanda K
Freeman, Christine M
Christenson, Stephanie A
Peters, Stephen P
Wells, J Michael
Doerschuk, Claire
Putcha, Nirupama
Barjaktarevic, Igor
Woodruff, Prescott G
Cooper, Christopher B
Bowler, Russell P
Comellas, Alejandro P
Criner, Gerard J
Paine, Robert
Hansel, Nadia N
Han, Meilan K
Crystal, Ronald G
Kaner, Robert J
Ballman, Karla V
Curtis, Jeffrey L
Martinez, Fernando J
Cloonan, Suzanne M

June 2020

Levels of iron and iron-related proteins including ferritin are higher in the lung tissue and lavage...

Characterisation of macrophage iron metabolism in interstitial lung disease

Boz, Cecilia Isotta

June 2022

INTRODUCTION: Interstitial lung disease (ILD) is used to describe a heterogeneous group of disorde...

Lung iron phenotype in CFTR KO mice.

Jean-Christophe Deschemin (405605)
Sarah Allouche (841657)
Franck Brouillard (369687)
Sophie Vaulont (186278)

January 2016

<p>Representative images of BAL (bronchoalveolar lavages) cytospin slides obtained from WT and CFTR ...

conflicts of interest.

Takahisa Gono
Kouhei Miyake
Yasushi Kawaguchi
Hirotaka Kaneko
Mikiko Shinozaki
Hisashi Yamanaka

January 2012

functionally distinct subunits: H-ferritin and L-ferritin [9]. H-ferritin plays the major role in th...

Phenotype of the isolated human lung macrophages.

Noemi Cifani (351531)
Barbara Pompili (447559)
Marco Anile (351534)
Miriam Patella (447560)
Daniele Diso (447561)
Federico Venuta (54700)
Giuseppe Cimino (447562)
Serena Quattrucci (199956)
Enea Gino Di Domenico (351532)
Fiorentina Ascenzioni (351535)
Paola Del Porto (124921)

August 2013

<p>A) Flow cytometric analysis of CD68 expression by lung macrophages stained with anti-CD68-FITC (b...

The IRONy of Iron-overload and Iron-deficiency in Chronic Obstructive Pulmonary Disease.

Cloonan, SM
Mumby, S
Adcock, IM
Choi, AMK
Chung, KF
Quinlan, GJ

April 2017

Chronic obstructive pulmonary disease (COPD) is a debilitating inflammatory lung disease associated ...

Preferential Macrophage Recruitment and Polarization in LPS-Induced Animal Model for COPD: Noninvasive Tracking Using MRI

Achraf Al Faraj (530923)
Asma Sultana Shaik (530924)
Mary Angeline Pureza (530925)
Mohammad Alnafea (530926)
Rabih Halwani (287270)

March 2014

<div><p>Noninvasive imaging of macrophages activity has raised increasing interest for diagnosis of ...

Hemosiderin in sputum macrophages may predict infective exacerbations of chronic obstructive pulmonary disease: a retrospective observational study

Sindu Mohan
Terence Ho
Melanie Kjarsgaard
Katherine Radford
A. S. M. Borhan
Lehana Thabane
Parameswaran Nair

April 2017

Abstract Background Infective exacerbations of COPD are common and are accompanied by neutrophilic b...

Iron is localized in macrophages in lung of COPD subjects and the percentage of iron positive macrophage increases with severity of disease.

Quentin Philippot (558140)
Gaëtan Deslée (3569186)
Tracy L. Adair-Kirk (307367)
Jason C. Woods (558141)
Derek Byers (558142)
Susan Conradi (558143)
Sandra Dury (59720)
Jeanne Marie Perotin (558144)
François Lebargy (59727)
Christelle Cassan (558145)
Richard Le Naour (359763)
Michael J. Holtzman (166602)
Richard A. Pierce (558146)

May 2014

<p>Perls-DAB and CD68 costaining was performed in lung samples obtained from (A–A’) a patient withou...

Flow cytometry analysis of alveolar macrophages in control/control, COPD/Control (48 h post LPS intrapulmonary exposition), COPD/M1 and COPD/M2 (2 h post-injection of iron-labeled macrophages) groups for both retained (i.e., iron loaded) and retained fractions.

Achraf Al Faraj (530923)
Asma Sultana Shaik (530924)
Mary Angeline Pureza (530925)
Mohammad Alnafea (530926)
Rabih Halwani (287270)

March 2014

<p>a- representative histogram of CD86 expression (higher row) and CD206 (lower row). b- Surface mem...

Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease.

Quentin Philippot
Gaëtan Deslée
Tracy L Adair-Kirk
Jason C Woods
Derek Byers
Susan Conradi
Sandra Dury
Jeanne Marie Perotin
François Lebargy
Christelle Cassan
Richard Le Naour
Michael J Holtzman
Richard A Pierce

Free iron in lung can cause the generation of reactive oxygen species, an important factor in chroni...

Increased Iron Sequestration in Alveolar Macrophages in Chronic Obtructive Pulmonary Disease

Quentin Philippot (558140)
Gaëtan Deslée (3569186)
Tracy L. Adair-Kirk (307367)
Jason C. Woods (558141)
Derek Byers (558142)
Susan Conradi (558143)
Sandra Dury (59720)
Jeanne Marie Perotin (558144)
François Lebargy (59727)
Christelle Cassan (558145)
Richard Le Naour (359763)
Michael J. Holtzman (166602)
Richard A. Pierce (558146)

May 2014

<div><p>Free iron in lung can cause the generation of reactive oxygen species, an important factor i...

Expression of CD73 and the A<sub>2B</sub>R in M2 macrophages.

Yang Zhou (65942)
Jayasimha N. Murthy (367141)
Dewan Zeng (367144)
Luiz Belardinelli (180279)
Michael R. Blackburn (104598)

February 2013

<p>Lung sections from COPD or IPF patients were reacted with antibodies against CD73 (A, green) or t...

ToF-SIMS mediated analysis of human lung tissue reveals increased iron deposition in COPD (GOLD IV) patients

Najafinobar, Neda
Venkatesan, Shalini
von Sydow, Lena
Klarqvist, Magnus
Olsson, Henric
Zhou, Xiao Hong
Cloonan, Suzanne M.
Malmberg, Per

January 2019

Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease that is currently the th...

Ferritin accumulated in medullary interstitial macrophages: Kidney sections from PIO mice were co-stained with anti-CD-68 and L-ferritin antibodies.

Avital Weiss (3490031)
Lior Spektor (5855732)
Lyora A. Cohen (5855735)
Lena Lifshitz (3202965)
Inbar Magid Gold (5855738)
De-Liang Zhang (5855741)
Marianna Truman-Rosentsvit (5855744)
Yael Leichtmann-Bardoogo (5855747)
Abraham Nyska (371249)
Sefi Addadi (1456258)
Tracey A. Rouault (126059)
Esther G. Meyron-Holtz (119365)

October 2018

Co-localization can be observed as yellow regions in the right panel. Scale bar represents 50μm.</p

Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS.

Zhang, William Z
Oromendia, Clara
Kikkers, Sarah Ann
Butler, James J
O'Beirne, Sarah
Kim, Kihwan
O'Neal, Wanda K
Freeman, Christine M
Christenson, Stephanie A
Peters, Stephen P
Wells, J Michael
Doerschuk, Claire
Putcha, Nirupama
Barjaktarevic, Igor
Woodruff, Prescott G
Cooper, Christopher B
Bowler, Russell P
Comellas, Alejandro P
Criner, Gerard J
Paine, Robert
Hansel, Nadia N
Han, Meilan K
Crystal, Ronald G
Kaner, Robert J
Ballman, Karla V
Curtis, Jeffrey L
Martinez, Fernando J
Cloonan, Suzanne M

June 2020

Levels of iron and iron-related proteins including ferritin are higher in the lung tissue and lavage...

Characterisation of macrophage iron metabolism in interstitial lung disease

Boz, Cecilia Isotta

June 2022

INTRODUCTION: Interstitial lung disease (ILD) is used to describe a heterogeneous group of disorde...

Lung iron phenotype in CFTR KO mice.

Jean-Christophe Deschemin (405605)
Sarah Allouche (841657)
Franck Brouillard (369687)
Sophie Vaulont (186278)

January 2016

<p>Representative images of BAL (bronchoalveolar lavages) cytospin slides obtained from WT and CFTR ...

conflicts of interest.

Takahisa Gono
Kouhei Miyake
Yasushi Kawaguchi
Hirotaka Kaneko
Mikiko Shinozaki
Hisashi Yamanaka

January 2012

functionally distinct subunits: H-ferritin and L-ferritin [9]. H-ferritin plays the major role in th...

Phenotype of the isolated human lung macrophages.

Noemi Cifani (351531)
Barbara Pompili (447559)
Marco Anile (351534)
Miriam Patella (447560)
Daniele Diso (447561)
Federico Venuta (54700)
Giuseppe Cimino (447562)
Serena Quattrucci (199956)
Enea Gino Di Domenico (351532)
Fiorentina Ascenzioni (351535)
Paola Del Porto (124921)

August 2013

<p>A) Flow cytometric analysis of CD68 expression by lung macrophages stained with anti-CD68-FITC (b...

The IRONy of Iron-overload and Iron-deficiency in Chronic Obstructive Pulmonary Disease.

Cloonan, SM
Mumby, S
Adcock, IM
Choi, AMK
Chung, KF
Quinlan, GJ

April 2017

Chronic obstructive pulmonary disease (COPD) is a debilitating inflammatory lung disease associated ...

Preferential Macrophage Recruitment and Polarization in LPS-Induced Animal Model for COPD: Noninvasive Tracking Using MRI

Achraf Al Faraj (530923)
Asma Sultana Shaik (530924)
Mary Angeline Pureza (530925)
Mohammad Alnafea (530926)
Rabih Halwani (287270)

March 2014

<div><p>Noninvasive imaging of macrophages activity has raised increasing interest for diagnosis of ...

Hemosiderin in sputum macrophages may predict infective exacerbations of chronic obstructive pulmonary disease: a retrospective observational study

Sindu Mohan
Terence Ho
Melanie Kjarsgaard
Katherine Radford
A. S. M. Borhan
Lehana Thabane
Parameswaran Nair

April 2017

Abstract Background Infective exacerbations of COPD are common and are accompanied by neutrophilic b...

Iron deposits and ferritin staining are colocalized in the same subset of macrophages (A) Costaining for ferritin and CD68 and (A’) with Perls-DAB and CD68 in two adjacent lung sections from a GOLD 4 COPD patient.

Abstract

Extracted data

Iron deposits and ferritin staining are colocalized in the same subset of macrophages (A) Costaining for ferritin and CD68 and (A’) with Perls-DAB and CD68 in two adjacent lung sections from a GOLD 4 COPD patient.

Abstract

Extracted data

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