Pedigree, haplotype analysis, and mutation analysis of the families in this study.

<p><b>A:</b> Pedigree and disease-haplotype segregation of family A. Blackened symbols represent affected individuals with an abnormal limb phenotype. White symbols represent individuals with a normal limb phenotype. Circles and squares indicate females and males, respectively. The arrows identify the proband and the disease-haplotype is boxed. <b>B:</b> Pedigree and disease-haplotype segregation of family B. <b>C: </b><i>HOXD13</i> missense mutations in the two families.