<i>In vitro</i> inhibition of MMP-9 by GM6001.

<p>Calibrated MMP-9 activity (Log 10⁶), as measured by a fluorescent electrophoretic technique, was dramatically attenuated by GM6001 <i>in vitro</i> at various concentrations. Plasma concentrations of GM6001, measured 96 hours following a single 100 mg/kg subcutaenous dose (range 0.16−.26 µM or 60–100 ng/mL), approximated those needed <i>in vitro</i> to robustly inhibit MMP-9 (0.2 µM or 77 ng/mL). Groups marked with an asterisk (*) had significantly (P<0.05) different calibrated MMP-9 activity from reference (no GM6001) using a one tailed Student’s t-test.