Administration of CpG IT and αCD137 IP significantly enhances survival of mice injected with a variety of SC tumors.

<p>Mice were injected subcutaneously with single cell suspensions of B16F10 (A, n = 5), Renca (B, n = 5–6), CT26 (C, n = 6–7, and E, n = 9–10) and MC38 (D, n = 6, and F, n = 5). When tumors reached an average of 20–50 mm² in size, mice were injected with CpG IT (every 2–3 days for 4 doses) and αCD137 IP (every 3–4 days for 3 doses), as outlined in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0095847#s2" target="_blank">Methods</a>, and survival of mice was monitored. * p&lt;0.05, ** p&lt;0.005, *** p&lt;0.0005.