HDAC2 knockdown mimicked the effect of melittin in HepG2 cells.

<p>HepG2 cells were transfected with HDAC2 siRNA for 24 h. The HDAC2 and PTEN mRNA expressions were analyzed by RT-PCR (a). The HDAC2, PTEN and ac-H3 proteins expression was analyzed by Western blot (b) and (c). Representative images from 3 to 4 independent experiments are shown. **P<0.01 vs control and scrambled siRNA.