Boxplots of weighted genetic risk score (wGRS) in MS patients and HC considering only HLA-DRB1, HLA-DRB1 + MS associations known in 2011 and HLA-DRB1 + all currently known MS associations.

<p><i>The wGRS was calculated by multiplying the number of risk alleles by the weight of each SNP and then taking the sum across all associations (see methods). The whiskers extend to the most extreme data point which is no more than 1.5 times the IQR from the box.</i>