Up-regulation of miR-130a-3p or miR-451a significantly changed MDA-MB-231 cells sensitivity to doxorubicin.

<p>A: Expression levels of miR-130a-3p or miR-451a were evaluated in different cell lines by qRT-PCR (** <i>P</i><0.01; *** <i>P</i><0.001, compared to MCF 10A). B: During doxorubicin treatment, miR-130a-3p or miR-451a were significantly down-regulated in MDA-MB-231 cells, respectively (*** <i>P</i><0.001, compared to vehicle control). C–D: Cells viability and cells apoptotic rate were analyzed by the cell counting kit-8 assay and flow cytometry, respectively (### <i>P</i><0.001, compared to vehicle control; * <i>P</i><0.05, ** <i>P</i><0.01, compared to Doxo group). All the results were obtained from three independent experiments. Doxo, doxorubicin.