<p>N.D.: not detectable.</p><p>a) RMSFs around C helices are large.</p><p>b) RMSFs around G helices are small.</p><p>c) RMSFs around I helices are large.</p><p>d) RMSFs around L helices are large.</p
Cytochrome P450 enzymes (CYPs) represent an important enzyme superfamily involved in metabolism of m...
In the RMSF graphs, the curves were normalized by subtracting the wild-type RMSF values from the CYP...
<div><p>Cytochrome P450 enzymes (CYPs) represent an important enzyme superfamily involved in metabol...
<p>(A) CYP2B6.4, (B) CYP2B6.8, (C) CYP2B6.11, (D) CYP2B6.12, (E) CYP2B6. 15, (F) CYP2B6. 18, (G) CYP...
<p>RMSD of CYP2B6.4 (A) converged, whereas that of CYP2B6.12 (B) did not converge at 20 ns.</p
<p><b>a)</b> Changes in the geometry of the protein tertiary structures. Wild type, red; CYP2A6*15, ...
<p>(A) Size-exclusion chromatography profiles. 100 µl of protein was loaded onto a Superdex 200 10/3...
(A) The CYP2D6 sequence is shown together with the location of the substrate recognition site (SRS1-...
<p>*34 has a single mutation at R296C (purple) on helix I and distal to the active site. *17-2 has t...
Purpose: To investigate the gene polymorphism of CYP2D6*10 (C188T) in the Hui people and study its c...
<p>Comparisons of backbone atoms RMSF in inhibitor C34 of wild type and N43D mutant.</p
in the metabolism of many clinically important sub-stances, but the variation within the CYP2B6 gene...
Hydrogen bonding network analysis of CYP2D6 variants, focus on mutated amino acids.</p
Cytochrome P450 enzymes (CYPs) represent an important enzyme superfamily involved in metabolism of m...
The SNPs are highlighted in red. SNPs in CYP2D6*2 are R296C and S486T, in CYP2D6*10 are P34S, S486T ...
Cytochrome P450 enzymes (CYPs) represent an important enzyme superfamily involved in metabolism of m...
In the RMSF graphs, the curves were normalized by subtracting the wild-type RMSF values from the CYP...
<div><p>Cytochrome P450 enzymes (CYPs) represent an important enzyme superfamily involved in metabol...
<p>(A) CYP2B6.4, (B) CYP2B6.8, (C) CYP2B6.11, (D) CYP2B6.12, (E) CYP2B6. 15, (F) CYP2B6. 18, (G) CYP...
<p>RMSD of CYP2B6.4 (A) converged, whereas that of CYP2B6.12 (B) did not converge at 20 ns.</p
<p><b>a)</b> Changes in the geometry of the protein tertiary structures. Wild type, red; CYP2A6*15, ...
<p>(A) Size-exclusion chromatography profiles. 100 µl of protein was loaded onto a Superdex 200 10/3...
(A) The CYP2D6 sequence is shown together with the location of the substrate recognition site (SRS1-...
<p>*34 has a single mutation at R296C (purple) on helix I and distal to the active site. *17-2 has t...
Purpose: To investigate the gene polymorphism of CYP2D6*10 (C188T) in the Hui people and study its c...
<p>Comparisons of backbone atoms RMSF in inhibitor C34 of wild type and N43D mutant.</p
in the metabolism of many clinically important sub-stances, but the variation within the CYP2B6 gene...
Hydrogen bonding network analysis of CYP2D6 variants, focus on mutated amino acids.</p
Cytochrome P450 enzymes (CYPs) represent an important enzyme superfamily involved in metabolism of m...
The SNPs are highlighted in red. SNPs in CYP2D6*2 are R296C and S486T, in CYP2D6*10 are P34S, S486T ...
Cytochrome P450 enzymes (CYPs) represent an important enzyme superfamily involved in metabolism of m...
In the RMSF graphs, the curves were normalized by subtracting the wild-type RMSF values from the CYP...
<div><p>Cytochrome P450 enzymes (CYPs) represent an important enzyme superfamily involved in metabol...
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