IFN-γ is deficiently produced in CF PBMCs in response to <i>B. cenocepacia.</i>

<p>1A) IFN-γ levels from the serum of 14 non-CF and 14 CF patients at the time of blood donation, p = 0.056, n = 14 subjects for each condition, Mann-Whitney testing. 1B) IFN-γ production from PBMC 24 hour cell supernatants from CF and non-CF patients. NT represents uninfected cells, and k56 were infected with <i>B. cenocepacia</i> k56-2. n = 8 subjects for NT and 10 subjects k56, Mann-Whitney testing. 1C) Immunoblot for IFN-receptor 1 from cell lysates of MDMs infected with k56-2+/− treatment with IFN-γ. 1D) Immunoblot for IFN-receptor β from cell lysates of MDMs infected with k56-2+/− treatment with IFN-γ.