The RLD group had a higher spike count (per min) than the SHD group.

<p>Spike counts were higher across all stages of seizures (A) or in the total spike count during the entire 2 h duration of SE following RLD (B). The increase in spike counts was significantly greater during stage-2 (p = 0.021) and stage-5 (p = 0.0012) seizures in the RLD group than in the SHD group (A). The mean values of spike rate shown at 5 min epochs revealed a significant increase in the RLD group than in the SHD group (two way ANOVA, p = 0.0001, n = 9 each). <b>C</b>: The spike amplitude during the 2 h SE was greater in stage-3B ≥ stage-2 > stage-3A ≥ stage-4 ≥ stage-5 > stage-1. There was a significant increase in spike amplitude for stage-5 seizures in the RLD group (p = 0.024, n = 9 each, unpaired t-test).