Locomotor deficits in MPTP-intoxicated mice treated with ND-602.

<p><b>A)</b> Following MPTP intoxication, animals displayed significantly reduced locomotor activity, as assessed by total distance traveled in one hour. However, MPTP failed to reduce locomotor activity in those animals treated with ND-602. Each bar represents the mean (±S.E.M., n = 5–6) distance traveled (cm) in one hour. <b>B)</b> The average velocity of locomotion was significantly reduced following MPTP intoxication. However, in those animals treated with viral ND-602, no such reduction was observed. Velocity in those animals was significantly higher than in their GFP-treated counterparts. Each bar represents the mean (±S.E.M., n = 5–6) velocity (cm/s) observed over a one hour period. <b>C)</b> When traversing the horizontal ladder, MPTP-treated animals displayed reduced locomotor coordination as evidenced by significantly more foot slips. However, in those animals treated with ND-602, no such elevation in foot slips was observed. Locomotor coordination in those animals was significantly better than in their GFP-treated counterparts. Each bar represents the mean (±S.E.M., n = 5–6) number of foot slips recorded. <b>D)</b> Following MPTP intoxication, animals took significantly longer to traverse a horizontal ladder. However, those animals treated with ND-602 showed no increase in travel time and were significantly faster than their GFP-treated counterparts. Each bar represents the mean (±S.E.M., n = 5–6) time(s) to traverse a horizontal ladder. **sig. diff. from vehicle control, <i>p</i><0.001; *<i>p</i><0.05. ++sig. diff. from GFP control, <i>p</i><0.001; +<i>p</i><0.05.