Hierarchical clustering of differentially expressed genes according to their GO BP terms semantic similarity.

<p>Annotated differentially expressed genes with a muscle fold change above 1.5 were clustered based on their functional annotation (GO BP) semantic similarity. Hierarchical clustering was performed using “1-semantic similarity” as distance between two genes (similar genes have a distance close to zero) to identify clusters of genes sharing BP terms. Five clusters were identified. Cluster 1 comprised 98 genes highly expressed in SM and 44 in LM. Cluster 2 included 73 highly expressed genes in SM and 102 in LM. Cluster 3 contained 43 highly expressed genes in SM and 84 in LM. Cluster 4 comprised 288 genes overexpressed in SM and 192 in LM. Cluster 5 involved 90 overexpressed genes in SM and 33 overexpressed genes in LM.