SVZ cell proliferation/migration, neural differentiation and infarct correlation 7 days post-stroke.

<p>Scatter plots of proliferating SVZ cells (Ki67+) from sham-operated (<i>n</i> = 3), 7 day post-stroke (<i>n</i> = 15) and 14 day post-stroke groups (<i>n</i> = 19) revealed a significant increase in the number of proliferating SVZ cells 7 days post-stroke (non-parametric ANOVA; A). Data presented as mean ± SEM, *<i>P</i><0.05 compared with sham-operated animals and #<i>P</i><0.05 compared with 7 day post-stroke animals. A significant correlation was found between proliferating SVZ cells (Ki67+) and infarct volume 7 days post-stroke (r = 0.73, <i>P</i><0.005, <i>n = </i>15; B) but not at 14 days (r = 0.07; C) (Pearson product moment correlation coefficients). Scatter plots depict a significant increase in proliferating radial glial cells within the SVZ at 7 days post-stroke (Mann Whitney test; D). Data presented as mean ± SEM, *<i>P</i><0.05 compared with sham-operated animals. Within the SVZ, a positive correlation was observed between infarct volumes and the number of proliferating radial glial cells (Ki67+/GFAP+; r = 0.73, <i>P</i><0.005; E) 7 days post-stroke (Pearson product moment correlation coefficients). Scatter plots depict a significant increase in the number of immature neuronal cells within the SVZ at 7 days post-stroke (DCX+, Mann Whitney test; F). Data presented as mean ± SEM, *<i>P</i><0.05 compared with sham-operated animals. Infarct volume significantly correlated with the number of immature neurons generated from the SVZ 7 days post-stroke (DCX+; r = 0.77, <i>P</i><0.001; G) (Pearson product moment correlation coefficients).