Altered tissue distribution of virus-specific CD8 T cells in <i>Socs4^R108X/R108X</i> mice.

<p>(A) Total numbers (BAL+MLN+SPL) of virus-specific (K^dNP₁₄₇ positive) CD8 T cells following X31 influenza virus infection. Mean values (n = 5) are plotted, error bars represent SEM. (B) Significant differences were observed in the distribution of K^dNP₁₄₇ positive CD8 T cells in lungs (BAL) and spleens of <i>Socs4^R108X/R108X</i> and Balb/c control mice following infection. *p<0.05, **<0.005, ***<0.001 (C) Percentage of GzmB positive K^dNP₁₄₇ positive CD8 T cells in various tissues on d10 post-infection (left hand panel); percentage of CD107a positive (middle panel) or GzmB positive (right hand panel) IFN-γ positive CD8 T cells on d10 post-infection following <i>ex vivo</i> stimulation with K^dNP₁₄₇ peptide. Mean values (n = 5) are plotted, error bars represent SD.