The distributions of the percentage of the genetic variation (A) and phenotypic variation (B) explained for cis- (black line) and trans- (blue line) eQTL.

A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

Ouwens, Klaasjan G.
Jansen, Rick
Nivard, Michel G.
van Dongen, Jenny
Frieser, Maia J.
Hottenga, Jouke-Jan
Arindrarto, Wibowo
Claringbould, Annique
van Iterson, Maarten
Mei, Hailiang
Franke, Lude
Heijmans, Bastiaan T.
't Hoen, Peter A. C.
van Meurs, Joyce
Brooks, Andrew
Penninx, Brenda W. J. H.
Boomsma, Dorret
Isaacs, Aaron
Pool, Rene
Hottenga, Jouke J.
van Greevenbroek, Marleen M. J.
Stehouwer, Coen D. A.
van der Kallen, Carla J. H.
Schalkwijk, Casper G.
Wijmenga, Cisca
Zhernakova, Sasha
Tigchelaar, Ettje F.
Slagboom, P. Eline
Beekman, Marian
Deelen, Joris
van Heemst, Diana
Veldink, Jan H.
van den Berg, Leonard H.
van Duijn, Cornelia M.
Hofman, Bert A.
Uitterlinden, Andre G.
Jhamai, P. Mila
Verbiest, Michael
Suchiman, H. Eka D.
Verkerk, Marijn
van der Breggen, Ruud
van Rooij, Jeroen
Lakenberg, Nico
van Galen, Michiel
Bot, Jan
Zhernakova, Dasha
van't Hof, Peter
Deelen, Patrick
Nooren, Irene
Moed, Matthijs

February 2020

Insights into individual differences in gene expression and its heritability (h(2)) can help in unde...

Estimation of the Proportion of Genetic Deviates Under the Assumptions of Normality

Thompson, K. H.
Federer, W. T.
Cornell University. Biometrics Unit.
Cornell University. Dept. of Biometrics.
Cornell University. Dept. of Biological Statistics and Computational Biology.

February 1962

6 pages, 1 article*Estimation of the Proportion of Genetic Deviates Under the Assumptions of Normali...

Distributions of nonzero effect size β of cis-eSNPs of L-SSMD genes in outlier and non-outlier individuals.

Yong Zeng (203681)
Gang Wang (36685)
Ence Yang (645612)
Guoli Ji (74496)
Candice L. Brinkmeyer-Langford (685968)
James J. Cai (266155)

January 2015

The effect size β is genotype-weighted (i.e., β =|β|*genotype, where genotype={0,1,2}).</p

Estimated genetic variance explained by eQTL SNPs and non-eQTL SNPs.

Kyung-Won Hong (348282)
Seok Won Jeong (672642)
Myungguen Chung (672643)
Seong Beom Cho (549402)

December 2014

Note. H2: previously reported heritability of the trait, Vg: estimated genetic variance, Vp: esti...

Cis and Trans Effects of Human Genomic Variants on Gene Expression - Figure 1

Julien Bryois (596234)
Alfonso Buil (29046)
David M. Evans (152874)
John P. Kemp (152856)
Stephen B. Montgomery (159816)
Donald F. Conrad (365590)
Karen M. Ho (596235)
Susan Ring (119324)
Matthew Hurles (56488)
Panos Deloukas (21564)
George Davey Smith (82619)
Emmanouil T. Dermitzakis (120302)

July 2014

(A) Histogram of heritability explained by the best cis-eQTL and (B) all independent cis-eQTLs fo...

Estimation of the proportion of genetic variation accounted for by DNA tests

R. M. Thallman
K. J. Hanford
R. L. Quaas
S. D. Kachman
R. J. Tempelman
L. Fern
L. A. Kuehn
E. J. Pollak

January 2009

An increasingly relevant question in evaluating commercial DNA tests is "What proportion of the...

Summary statistics and counts of cis- and trans-eQTLs at thresholds by R2 or |β|.

Maiko Narahara (582213)
Koichiro Higasa (23926)
Seiji Nakamura (126240)
Yasuharu Tabara (344614)
Takahisa Kawaguchi (158644)
Miho Ishii (389751)
Kenichi Matsubara (22850)
Fumihiko Matsuda (137136)
Ryo Yamada (8761)

June 2014

FDR: false discovery rate; FWER: family-wise error rate; SD: standard deviation; IQR: inter-quart...

Genetic variances and estimated broad-sense heritability of traits in the F3 population.

Fakhriddin N. Kushanov (4501048)
Zabardast T. Buriev (4110046)
Shukhrat E. Shermatov (4501042)
Ozod S. Turaev (4501045)
Tokhir M. Norov (4501051)
Alan E. Pepper (3273765)
Sukumar Saha (3547508)
Mauricio Ulloa (172013)
John Z. Yu (172023)
Johnie N. Jenkins (4110043)
Abdusattor Abdukarimov (3547505)
Ibrokhim Y. Abdurakhmonov (4110040)

October 2017

Genetic variances and estimated broad-sense heritability of traits in the F3 populatio...

Behavior genetics Analysis of variance

Omri Tal
O. Tal

October 2016

Abstract Can a heritability value tell us something about the weight of genetic versus environmental...

Cis and trans effects.

Frank W. Albert (133765)
Dale Muzzey (650142)
Jonathan S. Weissman (509877)
Leonid Kruglyak (4562)

October 2014

A. Parental differences (estimated based on SNP allele counts) on the x-axes, and hybrid differen...

Variance analysis and classification of phenotypically plastic and robust transcripts.

Shanshan Zhou (175668)
Terry G. Campbell (175675)
Eric A. Stone (120305)
Trudy F. C. Mackay (120308)
Robert R. H. Anholt (159214)

March 2012

(A, B) Relationships between coefficients of genetic variance of inbred lines (CVL) and coefficie...

Proportion of cis only and trans only genes identified as having dominant or additive inheritance.

Zachary H. Lemmon (655582)
Robert Bukowski (424557)
Qi Sun (127)
John F. Doebley (256204)

November 2014

The proportion of genes showing dominant (red) versus additive (blue) gene action for cis ...

List of variance-controlling QTL, the largest-effect marker within each QTL, the Brown-Forsythe statistics, P-value from genome-wide permutation, and proportion of trait variation (Vp) explained by the difference in mean (Vm) or variance (Vv) between two genotypes.

Cheng-Ruei Lee (650300)
Jill T. Anderson (650301)
Thomas Mitchell-Olds (35512)

October 2014

List of variance-controlling QTL, the largest-effect marker within each QTL, the Brown-Forsythe s...

Distributions of the width of our confidence intervals for eQTL in A & C) physical distance (kb) and B & D) genetic distance (cM) using either a 3 LOD drop (A & B) or the Bayesian credible interval (C & D).

Elizabeth G. King (561675)
Brian J. Sanderson (561676)
Casey L. McNeil (561677)
Anthony D. Long (207329)
Stuart J. Macdonald (561678)

May 2014

Black lines show CIs for cis-eQTL while blue lines show CIs for trans-eQTL.</p

Genetic Architecture of Genetic Variation in Gene Expression

Enrico Petretto (204195)
Jonathan Mangion (212668)
Nicholas J Dickens (2054)
Stuart A Cook (274553)
Mande K Kumaran (274555)
Han Lu (274557)
Judith Fischer (5243)
Henrike Maatz (274559)
Vladimir Kren (5650615)
Michal Pravenec (250703)
Norbert Hubner (20203)
Timothy J Aitman (274562)

February 2013

For each considered transcript the major eQTL was identified by linkage analysis (genome-wide sig...

A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

Ouwens, Klaasjan G.
Jansen, Rick
Nivard, Michel G.
van Dongen, Jenny
Frieser, Maia J.
Hottenga, Jouke-Jan
Arindrarto, Wibowo
Claringbould, Annique
van Iterson, Maarten
Mei, Hailiang
Franke, Lude
Heijmans, Bastiaan T.
't Hoen, Peter A. C.
van Meurs, Joyce
Brooks, Andrew
Penninx, Brenda W. J. H.
Boomsma, Dorret
Isaacs, Aaron
Pool, Rene
Hottenga, Jouke J.
van Greevenbroek, Marleen M. J.
Stehouwer, Coen D. A.
van der Kallen, Carla J. H.
Schalkwijk, Casper G.
Wijmenga, Cisca
Zhernakova, Sasha
Tigchelaar, Ettje F.
Slagboom, P. Eline
Beekman, Marian
Deelen, Joris
van Heemst, Diana
Veldink, Jan H.
van den Berg, Leonard H.
van Duijn, Cornelia M.
Hofman, Bert A.
Uitterlinden, Andre G.
Jhamai, P. Mila
Verbiest, Michael
Suchiman, H. Eka D.
Verkerk, Marijn
van der Breggen, Ruud
van Rooij, Jeroen
Lakenberg, Nico
van Galen, Michiel
Bot, Jan
Zhernakova, Dasha
van't Hof, Peter
Deelen, Patrick
Nooren, Irene
Moed, Matthijs

February 2020

Insights into individual differences in gene expression and its heritability (h(2)) can help in unde...

Estimation of the Proportion of Genetic Deviates Under the Assumptions of Normality

Thompson, K. H.
Federer, W. T.
Cornell University. Biometrics Unit.
Cornell University. Dept. of Biometrics.
Cornell University. Dept. of Biological Statistics and Computational Biology.

February 1962

6 pages, 1 article*Estimation of the Proportion of Genetic Deviates Under the Assumptions of Normali...

Distributions of nonzero effect size β of cis-eSNPs of L-SSMD genes in outlier and non-outlier individuals.

Yong Zeng (203681)
Gang Wang (36685)
Ence Yang (645612)
Guoli Ji (74496)
Candice L. Brinkmeyer-Langford (685968)
James J. Cai (266155)

January 2015

The effect size β is genotype-weighted (i.e., β =|β|*genotype, where genotype={0,1,2}).</p

Estimated genetic variance explained by eQTL SNPs and non-eQTL SNPs.

Kyung-Won Hong (348282)
Seok Won Jeong (672642)
Myungguen Chung (672643)
Seong Beom Cho (549402)

December 2014

Note. H2: previously reported heritability of the trait, Vg: estimated genetic variance, Vp: esti...

Cis and Trans Effects of Human Genomic Variants on Gene Expression - Figure 1

Julien Bryois (596234)
Alfonso Buil (29046)
David M. Evans (152874)
John P. Kemp (152856)
Stephen B. Montgomery (159816)
Donald F. Conrad (365590)
Karen M. Ho (596235)
Susan Ring (119324)
Matthew Hurles (56488)
Panos Deloukas (21564)
George Davey Smith (82619)
Emmanouil T. Dermitzakis (120302)

July 2014

(A) Histogram of heritability explained by the best cis-eQTL and (B) all independent cis-eQTLs fo...

Estimation of the proportion of genetic variation accounted for by DNA tests

R. M. Thallman
K. J. Hanford
R. L. Quaas
S. D. Kachman
R. J. Tempelman
L. Fern
L. A. Kuehn
E. J. Pollak

January 2009

An increasingly relevant question in evaluating commercial DNA tests is "What proportion of the...

Summary statistics and counts of cis- and trans-eQTLs at thresholds by R2 or |β|.

Maiko Narahara (582213)
Koichiro Higasa (23926)
Seiji Nakamura (126240)
Yasuharu Tabara (344614)
Takahisa Kawaguchi (158644)
Miho Ishii (389751)
Kenichi Matsubara (22850)
Fumihiko Matsuda (137136)
Ryo Yamada (8761)

June 2014

FDR: false discovery rate; FWER: family-wise error rate; SD: standard deviation; IQR: inter-quart...

Genetic variances and estimated broad-sense heritability of traits in the F3 population.

Fakhriddin N. Kushanov (4501048)
Zabardast T. Buriev (4110046)
Shukhrat E. Shermatov (4501042)
Ozod S. Turaev (4501045)
Tokhir M. Norov (4501051)
Alan E. Pepper (3273765)
Sukumar Saha (3547508)
Mauricio Ulloa (172013)
John Z. Yu (172023)
Johnie N. Jenkins (4110043)
Abdusattor Abdukarimov (3547505)
Ibrokhim Y. Abdurakhmonov (4110040)

October 2017

Genetic variances and estimated broad-sense heritability of traits in the F3 populatio...

Behavior genetics Analysis of variance

Omri Tal
O. Tal

October 2016

Abstract Can a heritability value tell us something about the weight of genetic versus environmental...

Cis and trans effects.

Frank W. Albert (133765)
Dale Muzzey (650142)
Jonathan S. Weissman (509877)
Leonid Kruglyak (4562)

October 2014

A. Parental differences (estimated based on SNP allele counts) on the x-axes, and hybrid differen...

Variance analysis and classification of phenotypically plastic and robust transcripts.

Shanshan Zhou (175668)
Terry G. Campbell (175675)
Eric A. Stone (120305)
Trudy F. C. Mackay (120308)
Robert R. H. Anholt (159214)

March 2012

(A, B) Relationships between coefficients of genetic variance of inbred lines (CVL) and coefficie...

Proportion of cis only and trans only genes identified as having dominant or additive inheritance.

Zachary H. Lemmon (655582)
Robert Bukowski (424557)
Qi Sun (127)
John F. Doebley (256204)

November 2014

The proportion of genes showing dominant (red) versus additive (blue) gene action for cis ...

List of variance-controlling QTL, the largest-effect marker within each QTL, the Brown-Forsythe statistics, P-value from genome-wide permutation, and proportion of trait variation (Vp) explained by the difference in mean (Vm) or variance (Vv) between two genotypes.

Cheng-Ruei Lee (650300)
Jill T. Anderson (650301)
Thomas Mitchell-Olds (35512)

October 2014

List of variance-controlling QTL, the largest-effect marker within each QTL, the Brown-Forsythe s...

Distributions of the width of our confidence intervals for eQTL in A & C) physical distance (kb) and B & D) genetic distance (cM) using either a 3 LOD drop (A & B) or the Bayesian credible interval (C & D).

Elizabeth G. King (561675)
Brian J. Sanderson (561676)
Casey L. McNeil (561677)
Anthony D. Long (207329)
Stuart J. Macdonald (561678)

May 2014

Black lines show CIs for cis-eQTL while blue lines show CIs for trans-eQTL.</p

Genetic Architecture of Genetic Variation in Gene Expression

Enrico Petretto (204195)
Jonathan Mangion (212668)
Nicholas J Dickens (2054)
Stuart A Cook (274553)
Mande K Kumaran (274555)
Han Lu (274557)
Judith Fischer (5243)
Henrike Maatz (274559)
Vladimir Kren (5650615)
Michal Pravenec (250703)
Norbert Hubner (20203)
Timothy J Aitman (274562)

February 2013

For each considered transcript the major eQTL was identified by linkage analysis (genome-wide sig...

A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

Ouwens, Klaasjan G.
Jansen, Rick
Nivard, Michel G.
van Dongen, Jenny
Frieser, Maia J.
Hottenga, Jouke-Jan
Arindrarto, Wibowo
Claringbould, Annique
van Iterson, Maarten
Mei, Hailiang
Franke, Lude
Heijmans, Bastiaan T.
't Hoen, Peter A. C.
van Meurs, Joyce
Brooks, Andrew
Penninx, Brenda W. J. H.
Boomsma, Dorret
Isaacs, Aaron
Pool, Rene
Hottenga, Jouke J.
van Greevenbroek, Marleen M. J.
Stehouwer, Coen D. A.
van der Kallen, Carla J. H.
Schalkwijk, Casper G.
Wijmenga, Cisca
Zhernakova, Sasha
Tigchelaar, Ettje F.
Slagboom, P. Eline
Beekman, Marian
Deelen, Joris
van Heemst, Diana
Veldink, Jan H.
van den Berg, Leonard H.
van Duijn, Cornelia M.
Hofman, Bert A.
Uitterlinden, Andre G.
Jhamai, P. Mila
Verbiest, Michael
Suchiman, H. Eka D.
Verkerk, Marijn
van der Breggen, Ruud
van Rooij, Jeroen
Lakenberg, Nico
van Galen, Michiel
Bot, Jan
Zhernakova, Dasha
van't Hof, Peter
Deelen, Patrick
Nooren, Irene
Moed, Matthijs

February 2020

Insights into individual differences in gene expression and its heritability (h(2)) can help in unde...

Estimation of the Proportion of Genetic Deviates Under the Assumptions of Normality

Thompson, K. H.
Federer, W. T.
Cornell University. Biometrics Unit.
Cornell University. Dept. of Biometrics.
Cornell University. Dept. of Biological Statistics and Computational Biology.

February 1962

6 pages, 1 article*Estimation of the Proportion of Genetic Deviates Under the Assumptions of Normali...

Distributions of nonzero effect size β of cis-eSNPs of L-SSMD genes in outlier and non-outlier individuals.

Yong Zeng (203681)
Gang Wang (36685)
Ence Yang (645612)
Guoli Ji (74496)
Candice L. Brinkmeyer-Langford (685968)
James J. Cai (266155)

January 2015

The effect size β is genotype-weighted (i.e., β =|β|*genotype, where genotype={0,1,2}).</p

The distributions of the percentage of the genetic variation (A) and phenotypic variation (B) explained for <i>cis</i>- (black line) and <i>trans</i>- (blue line) eQTL.

Abstract

Extracted data

The distributions of the percentage of the genetic variation (A) and phenotypic variation (B) explained for <i>cis</i>- (black line) and <i>trans</i>- (blue line) eQTL.

Abstract

Extracted data

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