Association between BMI and genotyped and imputed SNPs in black Health ABC participants.

<p>SNP genotypes from genome-wide Illumina array. Circles mark directly genotyped SNPs and triangles mark imputed SNPs. Gray points indicate association <i>P</i>-value >0.05. Red points indicate significant (<i>P</i>-value ≤0.05) associations with BMI. Anchor SNPs colored in blue. Purple circles mark SNP association with <i>MC4R</i> expression in HapMap YRI lymphoblastoid cell lines. In the panels showing trait association and eQTL <i>P</i>-values, the dashed line indicates cut-off value for Bonferroni-corrected <i>P</i>-value ≤0.05. LD heatmap indicates higher <i>r</i>² measures with darker red colors. Nucleotide conservation between the human and mouse is indicated on the top panel of the figure and was obtained using the VISTA browser.