Histology and serum transaminase levels in COX-2^−M/−M and COX-2^+/+ mice.

<p>H&E staining of liver sections (panel A) from COX-2^+/+ mice (a, c, e) and COX-2^-M/-M mice (b, d, f) revealed good histological preservation in naïve livers (a, b) and comparable extensive hepatic necrosis, vascular congestion, and disruption of liver architecture in COX-2^+/+ livers (c, e) and COX-2^−M/−M livers (d, f) at 6h (c, d), and 24h (e, f) after IRI. Serum AST and ALT levels (panel B) were also similar in COX-2^+/+ mice (black bars) and COX-2^−M/−M mice (white bars) after IRI; (n = 5-6/group).