Targeted gene delivery to MDA-MB-231 cell tumors in athymic mice.

<p>(<b>A</b>) Representative confocal micrographs of cells that were counterstained with FITC-phalloidin taken after a local (6 h) or intravenous (24 h) injection of NTS-polyplex nanoparticles carrying the plasmid pEGFP-N1 labeled with propidium iodide. One-micrometer optical sections in the x–y plane (Horizontal) and in the z plane (vertical). (<b>B</b>) Representative micrographs showing the expression of GFP in cells that were counterstained with Hoechst 33258 on day 3 after a local or intravenous injection of NTS-polyplex nanoparticles carrying the plasmid pEGFP-N1.