Effect of receptor levels on free VEGF fold change after anti-VEGF treatment.

<p>Fold change in free VEGF levels in response to anti-VEGF treatment using different representative receptor levels from the (A) C57BL/6 (C57) and (B) BALB/c (BAL) mice data. VEGFR1 and VEGFR2 levels were both updated in the model with geometric mean (2,100 VEGFR1/C57, 1,540 VEGFR2/C57, 2,700 VEGFR1/BAL, 1,900 VEGFR2/BAL), arithmetic mean (2,970 VEGFR1/C57, 2,180 VEGFR2/C57, 3,850 VEGFR1/BAL, 2,690 VEGFR2/BAL), mode (1,820 VEGFR1/C57, 2,860 VEGFR2/C57, 1,700 VEGFR1/BAL, 1,200 VEGFR2/BAL), and median (2,050 VEGFR1/C57, 1,510 VEGFR2/C57, 2,650 VEGFR1/BAL, 1,800 VEGFR2/BAL). Fold change is relative to control fold change, reflecting the normalized fold change obtained using previously published receptor levels (1,100 VEGFR1/cell and 700 VEGFR2/cell) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0097271#pone.0097271-FinleySDEngelStefanini1" target="_blank">[23]</a>.