Chemical inhibition of <i>T. b. brucei</i> cathepsins in the presence of ICP has no effect on human serum trypanolytic activity.
- Sam Alsford (24967)
- Rachel B. Currier (144838)
- José Afonso Guerra-Assunção (166779)
- Taane G. Clark (106263)
- David Horn (24969)
Publication date
May 2014
DOIAbstract
<p>(<b>A</b>) FMK024 fails to synergise with NHS against wild-type <i>T. b. brucei</i>; isobologram analysis showing 50% fractional inhibitory concentrations (FIC); dashed line indicates the expected output for no interaction. (<b>B</b>) Individual NHS EC<sub>50</sub> curves generated in the presence of 5 to 160 nM FMK024; bars represent standard error.</p
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