Model of HLM006474 synergy with paclitaxel.

<p>In untreated cells, E2F/dimerization partner (DP)/Rb complexes predominate, and thus, E2F3 levels are relative low (as well as many other E2F-regulated genes). Treatment with HLM006474 disrupts the E2F/DP/Rb repressive complexes from binding DNA, resulting in increased transcription of E2F3 (as well as many other E2F-regulated genes). In this model, the elevated levels of E2F3 sensitize cells to taxane treatment, as previously demonstrated, through an unknown mechanism.