The First One-Pot Synthesis of l‑7-Iodotryptophan from 7‑Iodoindole and Serine, and an Improved Synthesis of Other l‑7-Halotryptophans

A simple and scalable one-pot biotransformation enables direct access to l-halotryptophans, including l-7-iodotryptophan, from the corresponding haloindoles. The biotransformation utilizes an easy to prepare bacterial cell lysate that may be stored as the lyophilizate for several months and utilized as a catalyst as and when required