Dynamic contrast-enhanced MRI during tumor progression.

<p>(Left column) AUC₉₀ maps (mM⋅min) are overlaid on <i>T</i>₁-weighted spin-echo images acquired post-contrast injection (A) 6 days, (B) 13 days, and (C) 20 days after cell inoculation in the mammary fat pad. Arrow points to tumor. (Middle column) Corresponding signal enhancement time-course is shown for the tumor rim (solid line) and tumor core (dashed line). (Right column) Corresponding histograms of AUC₉₀ distributions show an evolution toward lower AUC₉₀ values.