Data from animals that developed GPIAS deficits between 3 and 6 weeks post-trauma Histograms in A and B show % GPIAS before acoustic trauma (AT), after AT and after treatment.

<p>A: Data from 4 animals given furosemide (black bars) and 3 animals given saline (white bars). All animals shown in A showed significant PPI. B: Data from 4 animals with significant PPI which were given furosemide (black bars, same animals as in panel A) and 3 animals without significant PPI which were also given furosemide (white bars). Significance is shown from repeated measure two-way ANOVA and post-tests. Statistical significance: *p<0.05; **p<0.01. ***p<0.001. C: CAP thresholds from animals shown in A (mean ± SEM). Left cochlea before acoustic trauma (open circles), immediately after acoustic trauma (black diamonds) and after recovery from acoustic trauma (open triangles). Contralateral control cochlea after recovery (black circles). Statistical significance of differences between pre and post acoustic trauma data: #p<0.001. D: Threshold loss for individual animals shown in A. Black symbols are animals given furosemide and open symbols animals given saline.