AdV-ZFP-VEGF improves hindlimb weight support.

<p>Catwalk gait analysis was used to assess hindlimb weight support. A sub-set of animals (with BBB scores >9) were assessed every week between 4–8 weeks, and each animal performed a standardized Catwalk run. A blinded observer analyzed the data. (A) Paw area: the maximal area of the paw print in contact with the detection surface of the CatWalk (expressed in mm²), (B) Paw width: the maximal distance spanning the medial and lateral contact points of the paw (expressed in mm), and (C) Paw length: the maximal distance spanning the cranial and caudal contact points of the paw (expressed in mm). (D) Representative images of CatWalk forelimb (green) and hindlimb (red) prints, which were used to quantify the data presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0096137#pone-0096137-g006" target="_blank">Figure 6</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0096137#pone-0096137-g007" target="_blank">Figure 7</a>. Data presented is the mean ± SEM, n = 5/group, at 8 weeks following SCI. One-way ANOVA (Holm-Sidak post-hoc). *p<0.05, **p<0.005.