We often need to report on environmental, economic and social indicators, and properties at aggregated spatial scales, e.g. average income per suburb. To do this, we invariably create reporting polygons that are somewhat arbitrary. The question arises: how much does this arbitrary subdivision of space affect the outcome? In this paper, we develop a new, gradient-based framework for carrying out a rigorous analysis of the sensitivity of integrating functions to quantitative changes in their spatial configuration. This approach is applied to both analytical and empirical models, and it allows the reporting of a hierarchy of sensitivity measures (from global to local). We found that the concepts of a vector space representing the spatial confi...