Time-dependent changes in the central conduction times following traumatic brain injury and HBO treatment established by somatosensory-evoked potentials.

<p>A. Schematic representation of the somatosensory-evoked potential recording sites adapted from the human 10–20 system. B. The central conduction time (CCT) is calculated by subtracting the peak latency of the major response from the neck from the latency of the primary cortical response C. Time-dependent modulation in the central conduction time recorded at the ipsi- and contralateral hemisphere in treated and untreated brain injured rats. Open square: HBO-treated brain injured rats; open circle: untreated brain injured rats; ---- baseline recordings; The HBOT effect was not observed at all time points (repeated measures mixed model ANOVA; <i>F(1,20) = 0.38, n.s.</i>); however, there was a significant effect at 3 weeks. *<i>p<</i>0.05 (repeated measures ANOVA, Bonferonni corrected); ^#<i>p</i>≤0.003 (t-test), HBO-treated versus untreated injured animals. ^##<i>p<0.001</i> (ANOVA), HBO-treated animals versus sham controls; n = 5 for untreated, n = 12 for HBO-treated (uneven group sizes arise from missing data points in some animals, which were excluded in repeated measures mixed model ANOVA). Error bars represent ± standard error means.