Effect of reversing remodeling of individual targets on CaT and AP characteristics in cAF.

<p>(A) chronic atrial fibrillation (cAF: all). (B–E) four restored cellular components (L-type Ca²⁺ current, I_CaL; inward rectified K⁺ current, I_K1; Na⁺/Ca²⁺ exchanger current, I_NCX; and increased cell volume, dilation), respectively. Columns from left to right: action potential (AP), Ca²⁺ transient (CaT) averaged over cell volume, and spatiotemporal presentation of CaT (x = distance from sarcolemma). Colour scale for right column: 0–1.5 µM corresponds to dark blue – dark red (similar to <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003620#pcbi-1003620-g001" target="_blank">Figure 1</a> F&G). All results are obtained at BCL = 1000 ms.