PF-04991532 improves glucose metabolism in rats.

<p>PF-04991532 increased the rate of glucose infusion in order to maintain hyperglycemia in Goto-Kakizaki rats (n = 6/group) (<b>A</b>) which can be attributed to the increased glucose disposal and decreased glucose production (n = 6/group) during steady state (<b>B</b>). PF-04991532 decreased plasma glucose in Goto-Kakizaki rats over 28 days of dosing (n = 6–8/group) [P<0.05 for 30, 60, and 100 mg/kg compared to vehicle] (<b>C</b>) which was accompanied by an increase in plasma triglycerides at the highest dose (n = 6–8/group) [P<0.05 for 100 mg/kg] (<b>D</b>). These plasma changes were not associated with any changes in liver triglycerides compared to vehicle treated animals (<b>E</b>). **P<0.01 One-way ANOVA and Tukey’s Multiple Comparison Test were used for A,C,D, & E. Student’s t-test was used for B.