Docking at α adrenergic receptors.

<p>Hypothetical binding modes of selected compounds at homology models of the hα_2B and hα_2C adrenergic receptors based on the h5HT_1B receptor structure. (A) Compounds <b>8</b> (yellow carbons) and <b>9</b> (cyan carbons) at the α_2B receptor. (B) Compounds <b>1</b> (orange carbons), <b>8</b> (yellow carbons) and <b>9</b> (cyan carbons) at the α_2C receptor. Ligands are show in ball and stick and some residues important for ligand recognition are shown in stick (gray carbons). Hydrogen atoms are not displayed. H-bonds are shown as black dashed lines. The Connolly surface of the amino acids surrounding the binding site is displayed. Surface color indicates the lipophilic potential: lipophilic regions (green), neutral regions (white) and hydrophilic regions (magenta).