Serum levels of Gd-IgA1-specific IgG in IgAN patients with high-Gd-IgA1 or normal-Gd-IgA1 in comparison to CKD and healthy controls.

<p>We divided IgAN patients into two subgroups: patients with serum levels of Gd-IgA1 ≥ the 90^th percentile for healthy controls (high-Gd-IgA1 group; n = 56) and patients with levels Gd-IgA1 < the 90^th percentile for healthy controls (normal-Gd-IgA1 group; n = 79). Although serum levels of Gd-IgA1-specific IgG were significantly higher in IgAN patients with high Gd-IgA1 levels (<i>vs.</i> CKD controls; *P<0.0001, <i>vs.</i> healthy controls; **P<0.0001), IgAN patients with normal Gd-IgA1 levels also had elevated Gd-IgA1-specific IgG (<i>vs.</i> CKD controls; *P<0.0001, <i>vs.</i> healthy controls; **P<0.0001).