Growth inhibition and apoptosis induction in <i>MYCN</i> amplified cells.

<p>(A) The amount of viable of cells was determined using crystal violet assay following 48 hours treatment of Kelly cells with increasing concentration of the indicated compound. Data are shown as percent of control (DMSO) treated cells and represent the mean of three independent experiments. Error bars indicate standard deviation. (B) Pearson's correlation between the IC₅₀ values in the growth inhibition assay (A, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0097285#pone-0097285-t002" target="_blank">Table 2</a>) and the K_D values for binding to MYCN (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0097285#pone-0097285-t001" target="_blank">Table 1</a>). (C–D) Quantification of apoptosis by propidium iodide staining for sub G1 DNA content of SK-N-BE(2) (C) and Kelly (D) cells. Data represent the means of at least three independent experiments. Error bars indicate standard deviation.