Brain histopathology of EV71 infected AG129 mice and of mice prophylactically protected with mAb 10D3.

<p>(<b>A</b>) Cross-section of brain stem from isotype control mice with arrows pointing to regions with neuropil vacuolation and neuronal loss without inflammation in the brain stem (at original magnification of 40×). (<b>B1–B3</b>) Higher power view of <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0002895#pntd-0002895-g007" target="_blank">Fig. 7A</a> at original magnification of 200×. (<b>C</b>) Cross-section of brain stem from mice prophylactically protected with mAb 10D3 showing no significant pathology (at original magnification of 40×). (<b>D</b>) Higher power view of <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0002895#pntd-0002895-g007" target="_blank">Fig. 7C</a> at original magnification of 200×.