Receptor intensity distribution patterns.

<p>A) Schematic representation of a model host-microbe contact site representing spatial distributions of DC-SIGN and CD206 intensity on the curved contact site membrane as a function of their spherical coordinates () relative to the yeast center. The dashed line depicts the boundary of the contact site as defined by DC plasma membrane stain present at the fungal cell wall edge. Within the contact area, there are regions of receptor colocalization and single receptor localization. B,C) Comparison of receptor total intensity over the entire contact for (B) DC-SIGN and (C) CD206 at times post exposure to yeasts (0, 1, 4 hours). D,E) Statistical comparison of total receptor intensity over the entire contact site for DC-SIGN at (D) one hour and (E) four hours post exposure. F,G) Statistical comparison of total receptor intensity over the entire contact site for CD206 at (F) one hour and (G) four hours post exposure. Statistical significance was determined by ANOVA, Tukey post-hoc test (*** and “A”: ; letter colors matched to figure legend) with samples per donor for 1 and 4 hours and samples per donor for 0 h. Comparisons are between the designated point and other time points of the same color (B,C) or between the different species of yeast (D,E,F,G). Values and error bars displayed in all panels are presented as means and standard deviations.