The effects of α2AP deficiency on anxiety-like behavior.

<p>The open field test showed that α2AP^−/− mice exhibited a shorter time in the center, indicating anxiety-like behavior (A), while there was little difference in the distance moved (B and C) (WT and α2AP^−/− mice, n = 11 and 10, respectively). In the dark/light transition test, there was little difference in the time spent in the dark compartment (D). However, the first latency to enter the light compartment was longer (E), and the number of transitions in the α2AP^−/− mice was lower than in the WT mice (F), indicating that the deletion of α2AP caused anxiety-like behavior (WT and α2AP^−/− mice, n = 11 and 10, respectively). The values represent the means±S.E. Significance was evaluated using Student’s <i>t</i>-test or an ANOVA with a LSD post-hoc test. *P<0.05, **P<0.01.