<i>Spon1</i>^−/− mice have increased trabecular and cortical bone.

<p>(A) Representative 3D µCT images showing regions of trabecular bone in the distal femur (F) and proximal tibia (T). Graphs represent measurements of total body weight (g), trabecular bone volume (bone volume per tissue volume, BV/TV), trabecular number (Tb.N/mm) and trabecular spacing (Tb.sp/mm) in the femurs and tibiae of 3 month (n = 4), 6 month (n = 10–11) and 12 month (n = 6) -old <i>Spon1</i><b>⁻</b>^/− and WT mice. (B) Representative 3D µCT images showing regions of femoral cortical bone in WT and <i>Spon1</i><b>⁻</b>^/− mice. Graph represents measurement of total area (Tt.Ar mm²), cortical area (Ct.Ar mm², cortical thickness (Ct.Th/mm) and intracortical porosity (%) of 6 month (n = 6–11) and 12 month (n = 5) mice. Arrows show the irregular surfaces along the endosteal perimeters of <i>Spon1</i><b>⁻</b>^<i>/</i>− mice. Statistically significant differences from WT mice groups are indicated by *(<i>P</i><0.05).