GSNO potentiates cisplatin induced cytotoxicity in A2780 bearing nude mice.

<p><b>A</b>. Schematic diagram of experimental design. <b>B</b>. Cumulative excised tumor weight from individual mice at 4 weeks with S-nitrosoglutathione (GSNO; 1 mg/kg of body weight) (panel 2), cisplatin (4 mg/kg of body weight) (panel 3) and GSNO (1 mg/kg of body weight) and cisplatin (4 mg/kg of body weight) combination (panel 4). Cisplatin was given 3 times by intraperitoneal route at day 7, 14 and 21 post-tumor injections. Results are shown as mean ± SD of 7 individual animals. ***p<0.001 combination of GSNO + cisplatin treated group compared to untreated or cisplatin alone treated group; **p<0.01 GSNO treated group compared to untreated group; *p<0.05 cisplatin treated group compared to untreated group; #p<0.05 combination of GSNO + cisplatin group compared to GSNO alone group.