Fully immature DENV-2 particles exhibit basic infectivity on immature dendritic cells.
- Mareike K. S. Richter (188993)
- Júlia M. da Silva Voorham (177554)
- Silvia Torres Pedraza (571270)
- Tabitha E. Hoornweg (571271)
- Denise P. I. van de Pol (571272)
- Izabela A. Rodenhuis-Zybert (177560)
- Jan Wilschut (177577)
- Jolanda M. Smit (177579)
Publication date
June 2014
DOIAbstract
<p>imDCs were infected with MOG 1000 of standard (std) or immature DENV-2. Supernatant was harvested 43 hpi and analyzed. (A) DENV-2 infectivity on imDCs. (B) Role of DC-SIGN on immature DENV-2 infectivity in imDCs as tested by DC-SIGN blockage. Limit of detection is 18 PFU/ml. Data are expressed as means of at least two independent experiments performed in triplicate; error bars represent standard error of the mean (SEM). N.d. denotes for “not detectable”. Levels of significance (Mann Whitney U test) are presented as ** = p<0.01.</p
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