Metastatic migration of the C33A-RFP cells in tumor-bearing nude mice.

<p><b>a</b> Migration of C33A-RFP cells in a lymph vessel connecting LN1 and RN1 42 dpti. Scale bars represent 2 mm. <b>b</b> LYVE-1 staining of 100 µm cross sections of the part between LN1 and RN1. Scale bars represent 200 µm. <b>c</b> Migration of C33A-RFP cells in a lymph (filled arrowhead) and in an erythrocyte containing blood vessel (open arrowhead) 32 dpti. Scale bars represent 2 mm (left) and 500 µm (right). <b>d</b> RFP signals in lungs of C33A-RFP tumor-bearing mice. Above: representative image of a lung 42 dpti. Scale bar represents 2 mm. Below: percentage of lungs tested positive for RFP spots over time. Lungs of six to seven mice per time point were examined (7 and 21 dpti: n = 7; 14, 28, 35 and 49 dpti: n = 6).