Imaging of primary osteosarcoma.

<p>Representative plain radiographs, histopathologic images, and 3D reconstructions from micro-computed tomography (μCT) of contralateral tumor free tibias. (A) and tibias injected with osteosarcoma cells (B). In tibias injected with osteosarcoma cells, trabecular bone in the medullary cavity is completely replaced by tumor, resulting in the osteolysis seen on radiographs (denoted by *). As tumor cells permeate and destroy cortical bone as they extend into the extra-osseous soft tissues, a vigorous osteoblastic periosteal reaction occurs, which corresponds to reactive woven bone deposition on the periosteal surface (arrows). Scale bar indicates 1.0 mm.