Methylation of <i>MIR-375 in</i> CRC cell lines and clinical samples using Infinium HumanMethylation450 BeadChips.
- Lise Lotte Christensen (93706)
- Anja Holm (571888)
- Juha Rantala (571889)
- Olli Kallioniemi (69616)
- Mads H. Rasmussen (571890)
- Marie S. Ostenfeld (571891)
- Frederik Dagnaes-Hansen (340355)
- Bodil Øster (394328)
- Troels Schepeler (79446)
- Heidi Tobiasen (571892)
- Kasper Thorsen (456075)
- Oliver M. Sieber (541264)
- Peter Gibbs (218861)
- Philippe Lamy (571893)
- Torben F. Hansen (571894)
- Anders Jakobsen (571895)
- Eva M. Riising (571896)
- Kristian Helin (10963)
- Jan Lubinski (59925)
- Rikke Hagemann-Madsen (571897)
- Søren Laurberg (571898)
- Torben F. Ørntoft (130553)
- Claus L. Andersen (571899)
Publication date
June 2014
DOIAbstract
<p>(A and C) Methylation of <i>MIR-375</i> in 8 CRC cell lines (A) and 12 normal colon mucosa samples paired with colorectal adenomas (n = 3) or adenocarcinomas (n = 9) (C). CpG sites in close proximity to <i>MIR-375</i> (CpG1-11) were analyzed. (B and D) Expression analysis of miR-375 in the CRC cells lines (B) and the paired clinical samples (RT-qPCR) (D). The miR-375 expression was measured in triplicates and normalized to miR-340. * indicate the pairs of clinical samples with significant miR-375 down-regulation (FC<sub>(log2)</sub>>1.5). N: normal colon mucosa, A: adenoma and C: adenocarcinoma.</p
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