A high-fat diet during pregnancy and lactation increases tau pathology in the hippocampus of female 3xTgAD offspring mice at 12 months of age.

<p>The Aβ extracelluar plaque burden (A) and the number of hyperphosphorylated tau-positive neurones/section (B) were assessed in the hippocampus of female offspring mice from dams fed a control or high-fat diet during pregnancy and lactation. Data are mean ± SEM for <i>n</i> = 5 per group. *<i>P</i><0.05. C-F are representative photomicrographs in the hippocampus of Aβ plaques (C–D) and hyperphosphorylated tau (E–F) detected by immunohistochemistry using 6E10 and AT8 antibodies, respectively. Scale bars: 100 µm.