A high-fat diet during pregnancy and lactation impairs memory in female 3xTgAD offspring mice at 2 months of age.

<p>Memory was assessed in female 3xTgAD offspring mice using the Y-maze spontaneous alternation test (A) and the Morris water maze (MWM) test (B–C). For the MWM mice were given four trials a day for 5 d of submerged platform training (B). Twenty-four hours after the final trial mice were given a probe test with no platform (C). Data are mean ± SEM for <i>n</i> = 5 per group. *<i>P</i><0.05 versus the target quadrant for control fed group.