Platelet supplementation effects on TEG coagulation measurements in fVdp and normal PFP.

<p>(A) While increasing the number of platelets in PFP has very little effect on the initiation of coagulation, a much more powerful response is observed in fVdp as platelets are increased from 10,000/mm³ to 100,000/mm³ (***: p<0.001 for the null hypothesis that PFP = fVdp; **: p<0.01; *: p<0.05; n.s.: not significant). Diminishing returns are seen in higher numbers of platelets, with no significant differences observed in the 300,000/mm³ and 400,000/mm³ concentrations of platelets compared with equivalent numbers in PFP. (B) Increasing platelets from 10,000/mm³ to 100,000/mm³ dramatically improves the alpha angle; the effect plateaus above 150,000 platelets/mm³. No alpha angle differences are observed due to the presence of fV protein in the plasma. (C) Similar to rate of clotting, strength of clot rises rapidly with increasing platelet counts until 100,000/mm³ where a plateau occurs. No significant differences are observed between fVdp and normal PFP with equal numbers of platelets. Means of three samples with standard deviation are shown.